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The clinical utility of basophil activation testing in diagnosis and monitoring of allergic disease
In this EAACI task force position paper, we provide an overview of the practical and technical details as well as the clinical utility of BAT in diagnosis and management of allergic diseases. Have a look! The clinical utility of basophil activation testing in diagnosis and monitoring of allergic disease Last updated: 23 September 2015 -
Nobel Prize in Physiology or Medicine 2013
The 2013 Nobel Prize in Physiology or Medicine is awarded to Dr. James E. Rothman, Dr. Randy W. Schekman and Dr. Thomas C. Südhof “for their discoveries of machinery regulating vesicle traffic, a major transport system in our cells”.
When a mast cell or a basophil granulocyte degranulates to release histamine and tryptase, SNARE complexes discovered by Dr Rothman induce fusion of vesicles with the cell wall and with each other. The degranulation process is probably regulated by synaptotagmin, MUNC-18 and complexin discovered by Dr Schekman and Dr Südhof. This process is not specific; it is the same process that controls the much faster nerve synapse mediator release.
This is the second Nobel prize to be awarded for discoveries related to cellular tests in allergy this century; the Nobel Prize in Chemistry 2008 was awarded jointly to Osamu Shimomura, Martin Chalfie and Roger Y. Tsien "for the discovery and development of the green fluorescent protein, GFP" one of the fluorochomes that could be used in the Basophil activation test.
HJ Hoffmann, chair IGAD
Last updated: 14 December 2014
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