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Pediatric Allergy and Immunology
The Pediatric Allergy and Immunology (PAI) is an official EAACI journal published in Wiley-Blackwell.PAI is a leading journal in the field of pediatric allergy, ranking 4th in Pediatrics, 8th in Allergy and 48th in Immunology, and with an impact factor of 4.137.
From 2018 onwards, PAI has a new Editor in Chief, Dr. Philippe Eigenmann. As a highly respected researcher and dedicated pediatrician, he aims to bring in new ideas and develop new ways of communication, thus increasing the high quality of PAI. Click on the video to see the interview with the new Editor in Chief.
We also take this opportunity to thank the past Editors in Chief, Ulrich Wahn, Paolo Matricardi, and Doris Kollmann who have been dedicated to our EAACI Journal PAI for the last eight years.
To go to the official journal's website, please click here.
To read the JM Must read articles click here.
Subscription to PAI is included in the EAACI membership. Members can access the full text through the Members Area.
How-To access EAACI Journals Allergy and Pediatric Allergy and Immunology for free online as an EAACI Member.Last updated: 15 October 2018 -
News from PAI
Is Europe overcoming childhood asthma?
Berlin, Germany, 7 September 2015 – Astonishing good news for the European health affairs came out from Rotterdam, The Netherlands, where scientists in Erasmus MC recently observed that childhood asthma rate is declining.
Read the full press release.Last updated: 15 October 2018 -
Highlights October 2018
Influence of genetic variants on childhood lung function - The generation R Study
Shagiwal SS, den Dekker HT, de Jongste JC et al. Pediatr Allergy Immunol. 2018;29:589-595.
https://doi.org/10.1111/pai.12931Last updated: 15 October 2018 -
Highlights September 2018
Table of Contents
Influence of genetic variants on childhood lung function – The Generation R Study
Shagiwal SS, den Dekker HT, de Jongste JC, et al. Pediatr Allergy Immunol. 2018;29:589–595.
doi.org/10.1111/pai.12931
Atopic dermatitis: Interaction between genetic variants of GSTP1, TNF, TLR2, and TLR4 and air pollution in early life
Hüls A, Klümper C, MacIntyre EA, et al. Pediatr Allergy Immunol. 2018;29:596‐605.
doi.org/10.1111/pai.12903
Wheeze trajectories are modifiable through early‐life intervention and predict asthma in adolescence
Owora AH, Becker AB, Chan‐Yeung M, et al. Pediatr Allergy Immunol. 2018;29:612–621.
doi.org/10.1111/pai.12922Last updated: 15 October 2018 -
Highlights August 2018
Table of Contents
What does lung function tell us about respiratory multimorbidity in childhood and early adulthood? Results from the MAS birth cohort study
D. Schramm, M. Reuter, L. B. Grabenhenrich, et. al. Pediatr. Allergy Immunol. 2018;29:481–489
DOI: 10.1111/pai.12901
Long‐term outcome of peanut oral immunotherapy—Real‐life experience
L. Nachshon, M. R. Goldberg, Y. Katz, et. al. Pediatr. Allergy Immunol. 2018;29:519-526
DOI: 10.1111/pai.12914
The impact of oral food challenges for food allergy on quality of life: A systematic review
H. M. Kansen, T. Le, Y. Meijer, et. al. Pediatr. Allergy Immunol. 2018;29:527-537
DOI: 10.1111/pai.12905
EAACI/ENDA Position Paper: Diagnosis and management of hypersensitivity reactions to non‐steroidal anti‐inflammatory drugs (NSAIDs) in children and adolescents
M. Kidon, N. Blanca‐Lopez, E. Gomes, et. al. Pediatr. Allergy Immunol. 2018;29:469–480
DOI: 10.1111/pai.12915Last updated: 16 August 2018 -
Highlights June 2018
Table of Contents
Increasing specific immunoglobulin E levels correlate with the risk of anaphylaxis during an oral food challenge
N. Yanagida, S. Sato, K. Takahashi, et. al. Pediatr. Allergy Immunol. 2018;29:417‐424.
DOI: 10.1111/pai.12896
Childhood asthma and smoking exposures before conception—A three‐generational cohort study
L. Bråbäck, C. J. Lodge, A.J. Lowe, et.al, Pediatr. Allergy Immunol. 2018;29:361‐368.
DOI: 10.1111/pai.12883
Wheezing preschool children with early‐onset asthma reveal a specific metabolomic profile
S. Carraro, S. Bozzetto, G. Giordano, et. al. Pediatr. Allergy Immunol. 2018;29:375‐382.
DOI: 10.1111/pai.12879Last updated: 25 June 2018 -
Highlights May 2018
Table of Contents
An approach to the asthma‐protective farm effect by geocoding: Good farms and better farms
S. E. K. Müller‐Rompa, I. Markevych, A. J. Hose, et. al. Pediatr Allergy Immunol. 2018;29:275‐282
DOI: 10.1111/pai.12861
Longitudinal vitamin D deficiency is inversely related to mite sensitization in early childhood
C‐Y Chiu, K‐W Su, M‐H Tsai, et. al. Pediatr Allergy Immunol. 2018;29:254‐259.
DOI: 10.1111/pai.12846
Association between pro‐inflammatory alleles and allergic phenotypes in Xhosa adolescents
L. Craig, L. van der Merwe, G. Zhang, et. al. Pediatr Allergy Immunol. 2018;29:311‐317
DOI: 10.1111/pai.12859Last updated: 25 June 2018 -
Highlights April 2018
Trajectory of spirometric and exhaled nitric oxide measurements in Chinese schoolchildren with asthma
F. Ting, Leung, M. F. Tang, A. S. Y. Leung, et. al. Pediatr Allergy Immunol. 2018;29:166‐173.
DOI: 10.1111/pai.12836
Risk factors for asthma occurrence in children with early‐onset atopic dermatitis: An 8‐year follow‐up study
C. Huang, T. Chiang, P. Chen, et. al. Pediatr Allergy Immunol. 2018;29:159‐165.
DOI: 10.1111/pai.12835
Does asthma affect school performance in adolescents? Results from the Swedish population‐based birth cohort BAMSE
S. Nilsson, M. Ödling, N. Andersson, et. al. Pediatr Allergy Immunol. 2018;29:174‐179.
DOI: 10.1111/pai.12855Last updated: 25 June 2018 -
Highlights March 2018
Table of Contents
Association of prenatal folate status with early childhood wheeze and atopic dermatitis
A. Roy, M. Kocak, T. J. Hartman, et. al. Pediatr Allergy Immunol 2018;29:144150.
DOI: 10.1111/pai.12834
Evaluation of a diagnostic therapeutic educational pathway for asthma management in youth
S. Guarnaccia, C. Quecchia, A. Festa, et. al. Pediatr Allergy Immunol 2018;29:180–185.
DOI: 10.1111/pai.12839
Association of leptin with disease severity and inflammation indicators in Chinese obese children with allergic rhinitis
W. Liu, Q. Zeng, L. Zhou, et. al. Pediatr Allergy Immunol 2018;29:186–193.
DOI: 10.1111/pai.12856Last updated: 25 June 2018 -
Previous Highlights
- FEBRUARY 2018
Mepolizumab—a novel option for the treatment of hypereosinophilic syndrome in childhood
Schwarz, C., et al. PAI. 2018;29: 28-33 DOI 10.1111/pai.12809
Physician's appraisal vs documented signs and symptoms in the interpretation of food challenge tests: The EuroPrevall birth cohort
Grabenhenrich, L., et al. PAI. 2018;29: 58-65 DOI 10.1111/pai.12811
Non-immediate-reading skin tests and prolonged challenges in non-immediate hypersensitivity to beta-lactams in children
Lezmi, G., et al. PAI. 2018;29: 84-89 DOI 10.1111/pai.12826
- DECEMBER 2017
Impact of pediatric obesity on acute asthma exacerbation in Japan
Okubo, Y., et al. PAI. 2017;28: 763-767 DOI 10.1111/pai.12801
Effects of treating helminths during pregnancy and early childhood on risk of allergy-related outcomes: Follow-up of a randomized controlled trial
Namara, B., et al. PAI. 2017;28: 784-792 DOI 10.1111/pai.12804
- NOVEMBER 2017
Vaccination and allergy: EAACI position paper, practical aspects
Nilsson L., et al. PAI. 2017;28: 628-640 DOI 10.1111/pai.12762
Vitamin D intake during the first 4 years and onset of asthma by age 5: A nested case-control study
Nwaru, B., et al. PAI. 2017;28: 641-648 DOI 10.1111/pai.12773
Cost of asthma in children: A nationwide, population-based, cost-of-illness study
Ferreira de Magalhaes, M., et al. PAI. 2017;28: 683-691 DOI 10.1111/pai.12772
- SEPTEMBER 2017
Prednisolone for the first rhinovirus-induced wheezing and 4-year asthma risk: A randomized trial
Koistinen A., et al. PAI. 2017;28: 557-563 DOI 10.1111/pai.12749
Neonatal BCG has no effect on allergic sensitization and suspected food allergy until 13 months
Thøstesen LM., et al. PAI. 2017;28: 588-596 DOI 10.1111/pai.12748
- AUGUST 2017
Nasal obstructive disorders impair health-related quality of life in adolescents with persistent allergic rhinitis: A real-life study
Valls-Mateus M., et al. PAI. 2017;28: 438-445 DOI 10.1111/pai.12724
Timing of food introduction and development of food sensitization in a prospective birth cohort
Tran MM., et al. PAI. 2017;28: 471-477 DOI 10.1111/pai.12739
- JUNE and JULY 2017
Eosinophilic esophagitis phenotypes: Ready for prime time?
Atkins D., et al. PAI. 2017;28: 312-319 DOI 10.1111/pai.12715
Safety and feasibility of heated egg yolk challenge for children with egg allergies
Yanagida N., et al. PAI. 2017;28: 348-354 DOI 10.1111/pai.12705
- MAY 2017
Incomplete and incorrect epinephrine auto-injector training to food-allergic patients by pharmacists in the Netherlands
Saleh-Langenberg J., et al. PAI. 2017;28: 238-244 DOI 10.1111/pai.12688
Phenotypical characterization of peanut allergic children with differences in cross-allergy to tree nuts and other legumes
Cousin M., et al. PAI. 2017;28: 245-250 DOI 10.1111/pai.12698
- MARCH 2017
Fish intake during pregnancy or infancy and allergic outcomes in children: a systematic review and meta-analysis
Zhang G-Q., et al. PAI. 2017;28: 152-161 DOI 10.1111/pai.12648
Nasal Obstructive Disorders induce medical treatment failure in Paediatric Persistent Allergic Rhinitis (The NODPAR Study)
Mariño-Sánchez FS., et al. PAI. 2017;28: 176-184 DOI 10.1111/pai.12679
- FEBRUARY 2017
Association between preschool eczema and medication for attention-deficit/hyperactivity disorder in school age.
Johansson EK.,et al. PAI. 2017;28: 44-50 DOI 10.1111/pai.12657
Identification of fungal candidates for asthma protection in a large population-based study.
Mueller-Rompa S., et al. PAI. 2017;28: 72-78 DOI 10.1111/pai.12665
Perceived exercise limitation in asthma: the role of disease severity, overweight, and physical activity in children.
Westergren T., et al. PAI. 2017;28: 86-92 DOI 10.1111/pai.12670
- DECEMBER 2016
Relationship between specific IgE to egg components and natural history of egg allergy in Danish children
Gradman, J., et al. PAI. 2017;27: 825-830 DOI 10.1111/pai.12644
Early gut colonization by Bifidobacterium breve and Bifidobacterium catenulatum differentially modulates eczema risk in children at high risk of developing allergic disease
Ismail, I., et al.PAI. 2017;27: 838-846 DOI 10.1111/pai.12646
Allergic rhinitis causes loss of smell in children: the OLFAPEDRIAL study
Langdon C., et al.PAI. 2017;27: 867-870 DOI 10.1111/pai.12655
- NOVEMBER 2016
No simple asnwers for the Finnish and Russian Karelia allergy contract: Methylation of CD14 gene
Khoo, S., et al. PAI. 2016;27: 721-727 DOI 10.1111/pai.12612
Exploration of early-life candidate biomarkers for childhood asthma using antibody arrays
Xu, H., et al. PAI. 2016;27: 696-701 DOI 10.1111/pai.12613
IL-33 polymorphisms are associated with increased risk of hay fever and reduced regulatory T cells in a birth cohort
Schroeder, P., et al. PAI. 2016;27: 687-695 DOI 10.1111/pai.12597
- SEPTEMBER 2016
The proportion of local allergic rhinitis to Dermatophagoides pteronyssinus in children
Buntarickpornpan P., et al. PAI. 2016;27: 574-579 DOI 10.1111/pai.12606
Allergic bronchopulmonary aspergillosis is associated with pet ownership in cystic fibrosis
Thronicke A., et al. PAI. 2016;27: 597-603 DOI 10.1111/pai.12590
Role of environmental exposures and filaggrin mutations on associations of ethnic origin with risk of childhood eczema. The Generation R Study
Elbert NJ., et al. PAI. 2016;27: 627-635 DOI 10.1111/pai.12579
- AUGUST 2016
Breastfeeding and asthma outcomes at the age of 6 years: the Generation R Study
den Dekker HT., et al. PAI. 2016;27: 3486-492 DOI 10.1111/pai.12576
The influence of inhaled corticosteroids on pubertal growth and final height in asthmatic children
De Leonibus C., et al. PAI. 2016;27: 499-506 DOI 10.1111/pai.12558
Periostin as a biomarker for the diagnosis of pediatric asthma
Inoue T., et al. PAI. 2016;27: 521-526 DOI 10.1111/pai.12575
- JUNE 2016
Prospective investigation on the transfer of Ara h 2, the most potent peanut allergen, in human breast milk
Schocker F., et al. PAI. 2016;27: 348-355 DOI 10.1111/pai.12533
Vitamin D3 for uncontrolled childhood asthma: a pilot study
Kerley CP., et al. PAI. 2016;27: 404-412 DOI 10.1111/pai.12547
Pre-birth cohort study of atopic dermatitis and severe bronchiolitis during infancy
Balekian DS., et al. PAI. 2016;27: 413-418 DOI 10.1111/pai.12532
- MAY 2016
Patient quality of life following induction of oral immunotherapy for food allergy
Epstein Rigbi N., et al. PAI. 2016;27: 263-268 DOI 10.1111/pai.12528
Exposure to mould allergens and rhinoconjunctivitis in Korean children
Hahm M-I., et al. PAI. 2016;27: 290-298 DOI 10.1111/pai.12520
Development and validation of asthma questionnaire for assessing and achieving best control in preschool-age children.
Sato K., et al. PAI. 2016;27: 307-312 DOI 10.1111/pai.12523
- MARCH 2016
Cows’ milk exclusion diet during infancy: Is there a long-term effect on children’s eating behaviour and food preferences?
Maslin K., et al. PAI. 2016;27: 141-146 DOI 10.1111/pai.12513
Key findings to expedite the diagnosis of hyper-IgE syndromes in infants and young children.
Hagl B., et al. PAI. 2016;27: 177-184 DOI 10.1111/pai.12512
Prescription patterns, adherence and characteristics of nonadherence in children with asthma in primary care.
Engelkes M., et al. PAI. 2016;27: 201-208 DOI 10.1111/pai.12507
- FEBRUARY 2016
The compliance and burden of treatment with the epinephrine auto-injector in food-allergic adolescents.
Saleh-Langenberg J., et al. PAI. 2016;27: 28-34 DOI 10.1111/pai.12458
Food-allergic infants have impaired regulatory T-cell responses following in vivo allergen exposure.
Dang TD., et al. PAI. 2016;27: 35-43 DOI 10.1111/pai.12498
Direct oral provocation tests in non-immediate mild cutaneous reactions related to beta-lactam antibiotics.
Vezir E., et al. PAI. 2016;27: 50-54 DOI 10.1111/pai.12493
- DECEMBER 2015
Ethnic differences in peanut allergy patterns in South African children with atopic dermatitis.
Gray CL., et al. PAI. 2015;26: 721-730 DOI 10.1111/pai.12459
Prenatal antibiotic use and risk of childhood wheeze/asthma: A meta-analysis.
Zhao D., et al. PAI. 2015;26: 756-764 DOI 10.1111/pai.12436
Improved management of childhood atopic dermatitis after individually tailored nurse consultations: A pilot study.
Rolinck-Werninghaus C., et al. PAI. 2015;26: 805-810 DOI 10.1111/pai.12338
- NOVEMBER 2015
Severity of rhinitis and wheezing is strongly associated in preschoolers: a population-based study.
Pereira AM., et al. PAI. 2015;26: 618-627 DOI 10.1111/pai.12430
Chemokine levels in serum of children with atopic dermatitis with regard to severity and sensitization status.
Ahrens B., et al. PAI. 2015;26: 634-640 DOI 10.1111/pai.12431
New method for single-breath FeNO measurement with improved feasibility in preschool children with asthma.
Heijkenskjöld-Rentzhog C., et al. PAI. 2015;26: 662-667 DOI 10.1111/pai.12447
- SEPTEMBER 2015
Ground zero: not asthma at all.
de Benedictis FM., et al. PAI. 2015;26: 490-496 DOI 10.1111/pai.12421
Obesity, asthma prevalence and IL-4: Roles of inflammatory cytokines, adiponectin and neuropeptide
Lu Y., et al. PAI. 2015;26: 530-536 DOI 10.1111/pai.12428
A population-based study of animal component sensitization, asthma, and rhinitis in schoolchildren
Bjerg A., et al. PAI. 2015;26: 557-563 DOI 10.1111/pai.12422
Fast food consumption in pregnancy and subsequent asthma symptoms in young children
von Ehrenstein OS., et al. PAI. 2015;26: 571-577 DOI 10.1111/pai.12433
- AUGUST 2015
Time to symptom improvement using elimination diets in non-IgE-mediated gastrointestinal food allergies
Lozinsky CA., et al. PAI. 2015;26: 403-408 DOI 10.1111/pai.12404
Diagnostic accuracy of patch test in children with food allergy
Sozmen C., et al. PAI. 2015;26: 416-422 DOI 10.1111/pai.12377
Asthma control in children is associated with nasal symptoms, obesity, and health insurance: a nationwide survey
Ferreira-Magalhães M., et al. PAI. 2015;26: 466-473 DOI 10.1111/pai.12395
- MAY 2015
Design and validation of pictograms in a pediatric anaphylaxis action plan
Mok G., et al. PAI. 2015;26: 223-233 DOI 10.1111/pai.12349
Dog and cat exposure and respective pet allergy in early childhood
Pyrhönen K., et al. PAI. 2015;26: 247-255 DOI 10.1111/pai.12369
Tacrolimus vs. cyclosporine eyedrops in severe cyclosporine-resistant vernal keratoconjunctivitis: a randomized, comparative, double-blind, crossover study
Pucci N., et al. PAI. 2015;26: 256-261 DOI 10.1111/pai.12360
- MARCH 2015
Wheat allergy in children evaluated with challenge and IgE antibodies to wheat components
Nilsson N., et al. PAI. 2015;26: 119.125 DOI 10.1111/pai.12334
Impact of elimination diets on growth and nutritional status in children with multiple food allergies
Berry MJ., et al. PAI. 2015;26: 133-138 DOI 10.1111/pai.12348
Rhinovirus-induced airway cytokines and respiratory morbidity in severely premature children
Perez GF., et al. PAI. 2015;26: 145-152 DOI 10.1111/pai.12346
- JANUARY 2015
Native and denatured egg white protein IgE tests discriminate hen's egg allergic from egg-tolerant children
Senouf AH., et al. PAI. 2015;26: 12-17 DOI 10.1111/pai.12317
Rhinitis in the First 18 months of Life: Exploring the Role of Respiratory Viruses
Hardjojo A., et al. PAI. 2015;26: 25-33 DOI 10.1111/pai.12330
Optimal duration of allergen immunotherapy in children with dust mite respiratory allergy
Arroabarren E., et al. PAI. 2015;26: 34-41 DOI 10.1111/pai.12296Last updated: 25 June 2018